📄 Category

psychiatry and clinical psychology

178 papers

Real World Effectiveness of Antipsychotic Treatment on Functional Outcomes Over Ten Years: A National Cohort of Patients in Denmark with Schizophrenia

This nationwide Danish cohort study of over 65,000 patients reveals that antipsychotic treatment exerts a time-dependent, biphasic effect on functional recovery, initially associated with reduced employment or education rates during the acute and consolidation phases (0–5 years) before showing a slight protective benefit in the long-term maintenance phase (5+ years).

Twumasi, R., Gronemann, F. H., Hjorthoj, C. + 4 more2026-04-02📄 psychiatry and clinical psychology

Wearable sensor data characterizes vigilance and avoidance behaviors in young children with mental health symptoms during a threat induction task

This study demonstrates that wearable inertial sensors can objectively quantify distinct threat response movement patterns in young children, revealing that internalizing symptoms are linked to vigilance behaviors while comorbid externalizing symptoms shift these responses toward avoidance, thereby offering a promising tool for early mental health screening.

Cohen, J. G., Mascia, G., Loftness, B. C. + 7 more2026-04-02📄 psychiatry and clinical psychology

Impact of AI-Powered Cognitive Behavioral Therapy Chatbot Access on Anxiety and Depressive Symptoms Among Primary Care Patients in Brazil: A Fuzzy Regression Discontinuity Design

Using a fuzzy regression discontinuity design on data from over 43,000 primary care patients in Brazil, this study provides causal evidence that access to an AI-powered CBT chatbot significantly reduces anxiety and depressive symptoms, with the most pronounced benefits observed among rural, less-educated, and female populations.

Ferreira, C., Lim, A.2026-04-02📄 psychiatry and clinical psychology

Evaluation of the effects of transcranial direct current stimulation on the effectiveness of cognitive function rehabilitation using the RehaCom system in patients with schizophrenia (study protocol)

This prospective, randomized, double-blind, sham-controlled clinical trial protocol outlines a study evaluating whether combining transcranial direct current stimulation (tDCS) targeting the dorsolateral prefrontal cortex with RehaCom-based cognitive remediation improves cognitive function and clinical outcomes in patients with schizophrenia compared to cognitive remediation alone.

Wysokinski, A., Szczakowska, A.2026-04-02📄 psychiatry and clinical psychology

Reliance on Prior Expectations in Psychosis: A Systematic Review and Meta-Analysis of Perceptual Tasks

This systematic review and meta-analysis of 27 studies involving over 1,900 participants found no evidence supporting the predictive processing theory that psychosis is characterized by a generalized aberrant reliance on prior expectations or specific associations with delusions and hallucinations.

Miller-Silva, C., Illingworth, B. J., Martey, K. + 4 more2026-04-01📄 psychiatry and clinical psychology

Mapping Individual Neuroanatomical Alterations to Schizophrenia Psychopathology with Normative Modeling

This study demonstrates that normative modeling of individual gray matter volume deviations, particularly within the salience network, effectively captures the clinical heterogeneity of schizophrenia spectrum disorders by significantly correlating with diagnostic status, symptom severity, and cognitive functioning.

Spaeth, J., Fraza, C., Yilmaz, D. + 17 more2026-04-01📄 psychiatry and clinical psychology

Speech-Based Markers in Paediatric ADHD: A Longitudinal Case-Control Study of Voice Features and Medication Effects

This longitudinal case-control study demonstrates that children with ADHD exhibit distinct baseline voice feature differences and medication-responsive changes compared to neurotypical controls, particularly during picture description tasks, supporting the potential of speech-based measures as objective digital biomarkers for diagnosis and treatment monitoring.

Bamberger, R., Kuhles, G., Lotter, L. D. + 6 more2026-03-31📄 psychiatry and clinical psychology

Anxiety Symptom Trajectories Following AI-Powered Cognitive Behavioral Therapy in United Kingdom Primary Care: A Multilevel Growth Curve Analysis of the NHS Digital Wellbeing Programme

This prospective cohort study of 6,284 patients in UK primary care reveals that while AI-powered CBT significantly reduces anxiety symptoms on average, treatment response is heterogeneous across four distinct trajectory classes, with outcomes influenced by baseline severity, engagement, and a notable deprivation-related gap, ultimately supporting the platform's role as a scalable intervention in capacity-constrained areas.

Lim, A., Pemberton, J.2026-03-31📄 psychiatry and clinical psychology

Vitamin D deficiency and depressive episodes in adolescents and young adults: systematic review and meta-analysis

This systematic review and meta-analysis of 20 studies involving nearly 28,000 adolescents and young adults concludes that vitamin D deficiency is significantly associated with depression, particularly among females, while noting that this association varies by age and is not significant for vitamin D insufficiency.

Nano, J. P., Catterall, W. A., Filer, V. + 4 more2026-03-30📄 psychiatry and clinical psychology

Mindfulness Meditation Training Reshapes Somatomotor Edge-Centric Connectivity Underlying Somatic Awareness: Insights for Healthy and Depressed Individuals

This study demonstrates that mindfulness meditation training reshapes somatomotor edge-centric connectivity to enhance somatic awareness, revealing both shared attentional mechanisms and population-specific neural pathways in healthy and depressed individuals that collectively predict improvements in insomnia.

He, Y., Lei, S. H., Che, W. S. + 18 more2026-03-30📄 psychiatry and clinical psychology

Developing a Tiered Machine Learning Alert System for Real-Time Suicide Risk Detection in a Digital Mental Health Setting

This paper presents a novel, tiered machine learning system that leverages fine-tuned transformer models and demographic data to accurately classify suicide risk into "no risk," "moderate," and "severe" categories within asynchronous text therapy, thereby enabling more timely and prioritized clinical interventions.

Donegan, M. L., Srivastava, A., Peake, E. + 7 more2026-03-30📄 psychiatry and clinical psychology

The Interplay of Spirituality and Self-Regulation in Youths: A Real-Time Examination of Mental Health Dynamics (SPIRIT)

This study employs a mixed-methods, multi-wave ecological momentary assessment approach to investigate the real-time, longitudinal interplay between spirituality, self-regulation, and mental health among adolescents and young adults, aiming to inform personalized preventive interventions.

Urben, S., Von Niederhausern, C., Ranjbar, S. + 2 more2026-03-30📄 psychiatry and clinical psychology

Sleeping with One Eye Open: Lived Experiences of Informal Caregivers Regarding Nighttime Agitation in People with Dementia

Through in-depth interviews with 15 informal caregivers, this study reveals that nighttime agitation in dementia severely impacts caregiver well-being and exposes a critical gap in current non-pharmacological interventions, underscoring the urgent need for integrative, dyadic approaches that prioritize caregiver support and systemic emergency resources.

Flisar, A., Van Den Bossche, M., Coppens, E. + 2 more2026-03-30📄 psychiatry and clinical psychology

A living systematic review, meta-analysis, and open data resource of trials of MDMA-assisted therapy for PTSD

This paper introduces a living systematic review and open-data resource analyzing six randomized controlled trials, which suggests that MDMA-assisted therapy significantly reduces short-term PTSD symptoms and increases response and remission rates, although the overall certainty of the evidence remains low and further research is needed.

Sevchik, B. L., Singleton, S. P., Lahey, A. + 10 more2026-03-30📄 psychiatry and clinical psychology

Older adults beliefs about coping strategies for anxiety: A UK-based multicultural qualitative study informed by Leventhals Common-Sense Model of Self-Regulation

This UK-based qualitative study of 52 older adults from diverse ethnic backgrounds reveals that while self-help strategies are the most common coping mechanism for anxiety, individual salient identities rather than cultural background drive strategy selection, highlighting the need for interventions that empower self-help while addressing barriers to formal care and acknowledging intra-group heterogeneity beyond the limitations of Leventhal's Common-Sense Model.

Alkholy, R., Bee, P., Pedley, R. + 1 more2026-03-30📄 psychiatry and clinical psychology

The exposome and attention-related brain networks jointly predict attention problems in early adolescence

Using data from over 11,000 adolescents, this study demonstrates that environmental exposures (the exposome) and attention-related brain network strength jointly and bidirectionally predict current and future attention problems, with brain networks partially mediating the impact of environmental factors.

Berrian, N., Keller, A. S., Chao, A. F. + 6 more2026-03-28📄 psychiatry and clinical psychology